CCT245737
CAY-28775-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
1489389-18-5
Formulation
A crystalline solid
Purity
≥98%
MW
379,340029
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A potent Chk1 inhibitor (IC50 = 1.3 nM); selective for Chk1 over Chk2 (IC50 = 2,440 nM); inhibits etoposide-induced G2 checkpoint arrest in HT-29 colon cancer cells (IC50 = 30 nM); inhibits gemcitabine-induced Chk1 autophosphorylation in an SW620 colon cancer mouse xenograft model at 300 mg/kg; reduces tumor volume when administered alone or in combination with gemcitabine in an HT-29 mouse xenograft model; reduces inguinal, brachial/axillary, and mesenteric lymph node weights in the Eμ-Myc driven transgenic mouse transplant model of lymph gland-infiltrating B cell lymphoma at 150 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
