Bestatin . hydrochloride
AG-CP3-7005-M025 25 mg
Synonyms: Ubenimex; NK421; NSC265489; N-(3R-Amino-2S-hydroxy-1-oxo-4-phenylbutyl)-L-leucine
Data Sheet: 
SDS:
SDS:
Source / Host
Synthetic. Originally isolated from S. olivoreticuli.
CAS
65391-42-6
Purity
>98% (HPLC)
MW
308.4 . 36.5
Shipment
Ambient
Short Term Storage
+4°C
Long Term Storage
-20°C
Shelf Life
Stable for at least 2 years after receipt when stored at -20°C.
Description
Chemical. CAS: 65391-42-6. Formula: C16H24N2O4 . HCl. Molecular Weight: 308.4 . 36.5. Antibiotic. Potent, competitive and specific aminopeptidase inhibitor. Can be administered in vitro to cultured cells or in vivo with low toxicity. Inhibits aminopeptidase B, aminopeptidase N, leucine aminopeptidase and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase. It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin and thermolysin. Immunomodulator. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays anticancer and anti-inflammatory activity. Shown to inhibit proliferation, migration and invasion, and induces autophagy and apoptosis in cancer cells. Inhibits the production of LTB4 in erythrocytes. Has been used as useful tool to assess the physiological role of certain mammalian exopeptidases in the regulation of the immune system, the growth of tumors and their invasion of surrounding tissues and the degradation of cellular proteins.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
