Berberrubine (chloride)
CAY-42515-50 50 mg
Data Sheet: 
SDS:
SDS:
CAS
15401-69-1
Formulation
A solid
Purity
≥98%
MW
357,78738
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An isoquinoline alkaloid with diverse biological activities; active metabolite of berberine; scavenges hydroxyl radicals and chelates ferrous iron in cell-free assays at 600 µM; potentiates topoisomerase II-induced cleavage of isolated E. coli DNA at 10 µM; inhibits MPP+ uptake in MDCK cells expressing human OCT1, OCT2, or OCT3 (IC50s = 1.26, 8.3, and 4.88 µM, respectively); decreases triglyceride levels without inducing cytotoxicity in HepG2 cells at 15 µM; increases intestinal length, decreases disease severity and colonic epithelial deterioration, reduces colonic TNF-α, IFN-γ, IL-6, IL-1β, IL-4, and IL-10 levels, and decreases colonic MPO activity in a mouse model of DSS-induced ulcerative colitis at 20 mg/kg per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
