Benzoylaconine
CAY-25687-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
466-24-0
Formulation
A crystalline solid
Purity
≥95%
MW
603,7
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An aconitine-type diterpenoid alkaloid that has been found in Aconitum species; increases protein levels of the efflux transporters P-glycoprotein, MRP2, and BCRP in LS174T cells in a concentration-dependent manner; increases the protein levels of P-glycoprotein in Caco-2 cells and the PXR in both Caco-2 and LS174T cells at 50 μM; reduces the cytotoxic effects of the P-glycoprotein substrates vincristine and doxorubicin in Caco-2 cells at 50 μM; increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice at 0.6 mg/kg; increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
