BMH-21
CAY-22282-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
896705-16-1
Formulation
A crystalline solid
Purity
≥95%
MW
360,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An RNA polymerase I inhibitor; inhibits expression of the 47S rRNA transcript (IC50 = 60 nM), disrupts the structure of the nucleolus, and leads to removal of the RNA polymerase complex from rDNA by inducing dissociation and destruction of RPA194 through a proteasome-dependent mechanism; activates p53 in the nanomolar range; reduces viability of several cancer cell lines but not of non-cancerous cells (IC50s = 0.7, 1.9, ≥40, and 2.7 µM for A375, human diploid fibroblasts, primary human melanocytes, and HIMEC cells, respectively); inhibits tumor growth in melanoma and colon cancer mouse xenograft models when used at a dose of 25 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
