BFH772
CAY-21386-1 1 mg
Data Sheet: 
CAS
890128-81-1
Formulation
A crystalline solid
Purity
≥95%
MW
439,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of VEGFR2 (IC50 = 0.0027 μM for the human receptor); selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2; inhibits VEGF-induced proliferation of HUVECs (IC50 = <0.01 nM); inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice at 1 and 3 mg/kg per day; inhibits primary tumor and metastasis growth in a B16 melanoma mouse model at 3 mg/kg per day
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
