Anti-Neurofilament heavy polypeptide, phosphorylated, (pNF-H) Antibody (NAP4)

  ABI-M-1387-50 50 µg

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Bovine, Chicken, Horse, Human, Mouse, Other Mammals (Predicted), Pig, and Rat  

FC, IF, ICC, IHC, WB  

NAP4  

25°C (ambient)  

Spin vial briefly before opening. Reconstitute with 50 µL sterile-filtered, ultrapure water to achieve a 1 mg/mL concentration. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C After reconstitution of lyophilized antibody,  

12 months after date of receipt (unopened vial).  

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Description

 

Our Anti-Neurofilament heavy polypeptide, phosphorylated (pNF-H) mouse monoclonal primary antibody detects bovine, chicken, horse, human, mouse, other mammals (predicted), pig, and rat Neurofilament heavy polypeptide, phosphorylated (pNF-H), and is IgG. It is validated for use in FC, IF, ICC, IHC, WB. - Neurofilaments are the 10 nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H, though other filament proteins may be included also. The major function of neurofilaments is likely to control the diameter of large axons. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at 68-70 kDa with some variability across species. Antibodies to NF-L are useful for identifying neuronal cells and their processes in cell culture and sectioned material. NF-L antibody can also be useful for the visualization of neurofilament rich accumulations seen in many neurological diseases, such as Lou Gehrig's disease (ALS), giant axon neuropathy, Charcot-Marie Tooth disease and others. (Ref: uniprot.org) -

 

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