Anti-CaSR Antibody

  ABI-305-CaSR 100 µL

Data Sheet:    

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Human, Mouse, and Rat  

ELISA, WB  

Lot Dependent  

Blue Ice  

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.  

After date of receipt, stable for at least 1 year at -20°C.  

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Description

 

Our Anti-CaSR rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat CaSR and is antigen affinity purified from pooled serum. It is great for use in WB. - Calcium sensing receptor, CaSR, is a unique G protein-coupled receptor activated by extracellular Ca2+, Mg2+, Sr2+, Mn2+, Ba2+, Ni2+, Al2+, Gd3+, amino acids, polyamines, pH and ionic strength (Quinn, S.J. et al., 1998). CaSR is a cell surface dimer located in the caveolin-rich plasma membrane domains (Kifor, O., et al., 1998). CaSR tightly regulates extracellular calcium levels to avoid hyper/hypo-calcemia through complex interactions with PTH, calcitonin, and vitamin D by balancing their effects on the parathyroid glands, bone, kidney, and intestine (Díaz-Soto, G. et al., 2016). Additionally, CaSR has been identified in the nervous system and recent studies suggest CaSR as a direct target of reducing Aβ42 secretion that may contribute to Alzheimer’s Disease (Armato, U., et al., 2013). Recent studies have shown CaSR negatively impacts the formation and progression of neuroblastomas by calcium exposure leading NB cells overexpressing CaSR to undergo apoptosis by means of activating ERK1/2 (Casalà, C., et al., 2013). -

 

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