Amylin Receptor 3 (AMY3R)/CRE Luciferase Reporter HEK293 Cell Line
BPS-83544 2 Vials
Synonyms: IAPP, DAP, IAP, islet amyloid polypeptide, Diabetes-associated peptide, Insulinoma amyloid peptide
Data Sheet: 
Reactivity
human
Applications
Screen or titrate Amylin receptor agonists.
Source / Host
human
Shipment
-80°C
Literature References
Bower R.L., et al., 2016 Br J Pharmacol. 173(12):1883-98
Kruse T., et al., 2021 Journal of Medicinal Chemistry 64(15): 11183-11194
Sonne N., et al., 2021 Mol Metab. 46:101109
Walker C.S., et al., 2025 Nat Rev Endocrinol. 21:482-494
Description
The Amylin Receptor 3 (AMY3R)/CRE Luciferase Reporter HEK293 Cell Line is a HEK293 cell line engineered to express CALCR (calcitonin receptor, NM_001164737.3) and RAMP3 (receptor activity modifying protein 3, NM_005856.3), delivered into CRE/CREB Luciferase Reporter HEK293 Cell Line (cAMP/PKA Signaling Pathway) (#60515), which expresses a firefly luciferase reporter driven by a multimerized cAMP response element (CRE). Activation of the receptor in these cells can be monitored by measuring luciferase activity.
This cell line was validated in dose-response assays using the peptide agonists Amylin, Calcitonin, Pramlintide, Cagrilintide, and Eloralintide. Purchase of this cell line is for research purposes only; commercial use requires a separate license. - Screen or titrate Amylin receptor agonists. - Avoid freeze/thaw cycles.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
