ASTX660
CAY-36619-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
1799328-86-1
Formulation
A solid
Purity
≥98%
MW
539,7
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A non-peptidomimetic inhibitor of IAP protein-peptide interactions; inhibits the protein-peptide interaction between the IAP1 and XIAP BIR3 domains with a Smac-derived peptide in cell-free assays (IC50s = 50 = 2.8 nM); induces displacement of Smac from XIAP in A375 melanoma cells; induces apoptosis in MDA-MB-231, A375, and SK-MEL-28 cells in a TNF-α-dependent manner; reduces tumor growth in MDA-MB-231 and A375 mouse xenograft models at 20 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
