ASP9521
CAY-27308-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
1126084-37-4
Formulation
A crystalline solid
Purity
≥98%
MW
330,42142
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An inhibitor of 17β-HSD5/AKR1C3 (IC50 = 120 nM); selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC50 = 20 μM); inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC50s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively); inhibits androstenedione-dependent PSA production in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3; inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model at 3 and 10 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
