AS-252424
CAY-10009052-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
900515-16-4
Formulation
A crystalline solid
Purity
≥95%
MW
305,3
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A PI3Kγ and ACSL4 inhibitor; inhibits PI3Kγ (IC50 = 0.03 µM); selective for PI3Kγ over PI3Kα, PI3Kβ, and PI3Kδ (IC50s = 0.94, 20, and 20 µM, respectively) but also inhibits CK2 (IC50 = 0.02 µM); prevents decreases in viability induced by RSL3 in HT-1080 cells in an ACSL4-dependent manner; nanoparticles loaded with AS-252424 reduce inflammation and ferroptosis in an ACSL4-dependent manner in the kidney and liver in mouse models of renal pedicle clamping-induced ischemia-reperfusion injury and concanavalin A-induced acute liver injury, respectively; reduces c-Kit ligand-induced LTC4 production and cPLA2, JNK, and p38 MAPK phosphorylation in bone marrow-derived mast cells at 0.5-2.5 µM; increases airway hyperresponsiveness and airway smooth muscle thickening in a mouse model of toluene diisocyanate-induced asthma at 10 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
