APS6-45
CAY-38417-1 1 mg
Data Sheet: 
CAS
2188236-41-9
Formulation
A solid
Purity
≥98%
MW
548,385525
Shipment
-20
Long Term Storage
-20
Description
An inhibitor of RETM918T and a derivative of sorafenib; selectively binds to RETM918T over EphA8, p38δ, JNK2, and c-Src (Kds = 28, 410, 940, 1,500, and 1,700 nM, respectively) and a panel of over 60 kinases at 10 µM, but also selectively binds to Cdk14, MAP4K4, and PTK5 (Kds = 55, 130, and 140 nM, respectively); inhibits TT cell colony formation at 30 nM; decreases tumor volume in a TT mouse xenograft model at 10 mg/kg per day; increases survival to adulthood in transgenic Drosophila expressing the lethal RetM955T mutation in a concentration-dependent manner; prevents the development of a rough-eye phenotype induced by RetM955T in transgenic Drosophila at 100 µM;
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
