AM966
CAY-22048-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
1228690-19-4
Formulation
A crystalline solid
Purity
≥98%
MW
490,9
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A potent and selective LPA1 receptor antagonist (IC50 = 17 nM); selective for LPA1 over the LPA2, LPA3, LPA4, and LPA5 receptors (IC50s = 1,700, 1,600, 7,700, and 8,600 nM for LPA2-5, respectively); inhibits LPA-induced lung fibroblast cell chemotaxis (IC50 = 181 nM); reduces inflammation, tissue fibrosis, and vascular permeability in mice at a dose of 30 mg/kg following bleomycin-induced lung injury; blocks amitriptyline-induced ERK1/2, CREB, and IGF-IR phosphorylation in vitro
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
