A-839977
CAY-30934-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
870061-27-1
Formulation
A crystalline solid
Purity
≥98%
MW
413,2597
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A P2X7 receptor antagonist; inhibits BzATP-evoked intracellular calcium influx in 1321N1 cells expressing human, rat, and mouse receptors (IC50s = 20, 42, and 150 nM, respectively); inhibits BzATP-induced YO-PRO dye uptake and IL-1β release from THP-1 cells (IC50s = 6.6 and 37 nM, respectively); reduces thermal hyperalgesia in rats at 30, 100, and 300 µmol/kg, i.p.; reduces thermal and mechanical hyperalgesia in a rat MRMT-1 mammary carcinoma model of cancer-induced bone pain at 40 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
