5,7-Dichlorokynurenic Acid
CAY-25533-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
131123-76-7
Formulation
A crystalline solid
Purity
≥98%
MW
258,1
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
An NMDA receptor antagonist (Ki = 40 nM in a radioligand binding assay); selectively selectively inhibits glycine- over kainate-induced NMDA currents at 15 μM in Xenopus oocytes expressing rat NMDA receptors; reduces NMDA-induced neurotoxicity in primary rat cortical neurons from 1 to 10 μM; reverses mechanical hyperalgesia in magnesium-deficient rats in a dose-dependent manner from 0.97-97 nmol; blocks the positive ionotropic effect, hypertension, and increase in myocardial oxygen demand induced by electrical stimulation of the PVN in anesthetized rabbits; increases social interaction time and time spent in the open arms of the elevated plus maze; disinhibits conflict responding in the Cook and Davidson conditioned conflict paradigm
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
