2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
CAY-22590-1 1 mg
![2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine](https://www.caymanchem.com/images/catalog/22590.png "2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine")
Data Sheet: 
SDS:
SDS:
CAS
105650-23-5
Formulation
A crystalline solid
Purity
≥98%
MW
224,3
Shipment
-20
Long Term Storage
-20
Shelf Life
730
Description
A food-derived carcinogen; metabolized by CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts; chronic treatment (1 pM/L for 20 cycles) of MCF-10A cells induces anchorage-independent cell growth and reduces cellular dependence on growth factors; increases wild-type H-Ras gene and protein expression which activates ERK signaling, MMP-2 and MMP-9 protein expression, and NOX1-driven production of ROS in vitro; increases tumor formation in a murine breast cancer xenograft model; induces formation of colon tumors with β-catenin gene mutations that hyperactivate the Wnt signaling pathway in a CYP1A2 humanized rat model; increases the occurrence of atypical hyperplasias and carcinomas in the ventral prostate and seminal vesicles of rats
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
