2-Acetyl-5-tetrahydroxybutyl Imidazole
CAY-13222-1 1 mg
Synonyms: 2-Acetyl-4-tetrahydroxybutyl Imidazole|2-ATHBI|THI
Data Sheet: 
SDS:
SDS:
CAS
94944-70-4
Formulation
A crystalline solid
Purity
≥95%
MW
230,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate (S1P) lyase in vivo.{13428} THI is not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation.{45874} In mice, THI (50 µg/ml in drinking water) increases S1P levels by 100-fold in lymphoid tissue and reduces lymphocyte egress from thymus and peripheral lymphoid organs.{13428,17443} The resulting lymphopenia is reversible following cessation of THI treatment.{17442}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
