CAS
58002-62-3
Formulation
A crystalline solid
Purity
≥98%
MW
231,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A cyclic analog of L-glutamate; binds to GluK1, GluK2, GluK3, GluK4, and GluK5 (Kis = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively); induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes at 5 mM; induces chromatin condensation and nuclear membrane fragmentation in primary neonatal cerebellar granule neurons at 100 µM; induces convulsive behavior in rats (ED50 = 0.51 nmol/animal) and induces seizures in mice (CD50 = 0.39 nmol/animal); has been commonly used to induce seizures in rodents
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).