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Histone Deacetylases (HDAC) & Histone Acetyltransferase (HAT)   

Eukaryotic DNA is highly organized and packaged into the nucleus. The organization and packaging are achieved through the addition of proteins, including core histones H2A, H2B, H3 and H4, which form a complex structure, the chromatin, together with DNA. The modification of core histones is of fundamental importance to conformational changes of the chromatin. The level of acetylation is related to transcription activity, and then the acetylation induces an open chromatin confirmation that allows the transcription machinery access to promoters. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the ε-amino groups of lysine located near the amino termini of core histone proteins. Chromatin acetylation correlates with transcriptional activity (euchromatin), whereas deacetylation correlates with gene silencing. HDACs are also involved in the reversible acetylation of non-histone proteins. Altered HDAC and/or HAT activities are present in many types of cancers.

Mammalian HDACs have been classified into three classes. Class I (HDACs 1, 2, 3 & 8; each of which contains a deacetylase domain exhibiting from 45% to 93% identity in amino acid sequence) are homologs of yeast RPD3 and localize to the nucleus. Class II (HDACs 4, 5, 6, 7, 9 & 10) are homologs of yeast Hda1 and are found in both the nucleus and cytoplasm. The molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. HDAC11 has properties of both class I and class II HDACs. Class III (Sirt1 - Sirt7) are homologs of yeast Sir2 and form a structurally distinct class of NAD-dependent enzymes found in both the nucleus and cytoplasm. 

Conserved from yeast to human, HDAC classes I and II are inhibited by trichostatin A (Prod. No. 380-068) and appear to use a divalent zinc-binding motif. The metal-coordinated active site activates an H2O molecule for direct targeting and hydrolysis of the acetyl group to form acetate. Acetylation of lysines in histones neutralizes the positive electric charge between the negatively charged DNA backbone and tips the balance towards relaxing the chromatin, while deacetylation would shift the balance back to condensing the chromatin and silencing gene expression. In a similar way PARP-1 adds to histones hundreds of negatively charged ADP-ribose units, which repel histones away from the negatively charged DNA backbone and thus induces chromatin relaxation to facilitate accession of DNA repair enzymes and gene expression. 

Unlike HDAC classes I and II, Sir2-like proteins catalyze a unique reaction, that like PARP-1, requires the coenzyme NAD+. In this reaction, nicotinamide is liberated from NAD+ and the acetyl group of the substrate is transferred to cleaved NAD+, generating the novel metabolite O-acetyl-ADP ribose. Due to the NAD+ dependency, Sir2 might be the link between metabolic activity and genome stability and, finally, aging.

Inhibitors of HDAC classes I and II emerge as potent anti-cancer agents. A proposed mechanism for the anti-tumor effects of HDAC inhibitors is that the accumulation of acetylated histones leads to activation (and repression) of the transcription of a selected number of genes whose expression causes inhibition of tumor cell growth and induction of apoptosis. 

Disruption of HDACs has been linked to a wide variety of human cancers. HDAC inhibitors have been shown to be potent inducers of growth arrest, differentiation, and/or apoptotic cell death. Some newly synthesized compounds are potentially effective agents for cancer therapy and, possibly, cancer chemoprevention.

Disruption of HDACs has been linked to a wide variety of human cancers. HDAC inhibitors have been shown to be potent inducers of growth arrest, differentiation, and/or apoptotic cell death. Some newly synthesized compounds are potentially effective agents for cancer therapy and, possibly, cancer chemoprevention.

 

HDAC Inhibitors  

 

 

Apicidin [cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]

ALX-350-095-M001

1 mg 

 

ALX-350-095-M005

5 mg 

5-Aza-2'-deoxycytidine

ALX-480-096-M005

5 mg 
CAY10398  CAY-89740-M001 1 mg 
  CAY-89740-M005 5 mg 
  CAY-89740-M010 10 mg 
  CAY-89740-M050 50 mg 
CAY10433  CAY-10005019-M001 1 mg 
  CAY-10005019-M005 5 mg 
  CAY-10005019-M010 10 mg 
  CAY-10005019-M050 50 mg 

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

ALX-270-437-M001

1 mg 

HC Toxin

ALX-630-102-M001

1 mg 

ITSA1

ALX-270-382-M005

5 mg 

 

ALX-270-382-M025

25 mg 

M344

ALX-270-297-M001

1 mg 

 

ALX-270-297-M005

5 mg 

MC 1293

ALX-270-344-M005

5 mg 

MS-275

ALX-270-378-M001

1 mg 

 

ALX-270-378-M005

5 mg 

 

ALX-270-378-M025

25 mg 

Oxamflatin

ALX-270-379-M001

1 mg 

 

ALX-270-379-M005

5 mg 
PXD101 CAY-10004279  
SAHA (Discontinued)    

Scriptaid

ALX-270-298-M001

1 mg 

 

ALX-270-298-M005

5 mg 

Sirtinol

ALX-270-308-M001

1 mg 

 

ALX-270-308-M005

5 mg 

Sodium butyrate

ALX-270-301-G001

1 g 

Sodium 4-phenylbutyrate

ALX-270-303-M100

100 mg 
Splitomicin  ALX-270-380-M001 1 mg 
  ALX-270-380-M005 5 mg 

    

ALX-270-380-M025

 25 mg 

Trichostatin A

ALX-380-068-M001

1 mg 

 

ALX-380-068-M005

5 mg 

Trichostatin A

CAY-89730-C500

500 g 

 

CAY-89730-M001

1 mg 

 

CAY-89730-M005

5 mg 

 

CAY-89730-M010

10 mg 

Valproic acid . sodium salt

ALX-550-304-G005

5 g 

 

 

 

Histone Deacetylase (HDAC) Fluorescent Substrate

 

 

Histone Deacetylase Substrate (Fluorometric)

ALX-260-137-M001

1 mg 

 

ALX-260-137-M005

5 mg 
Fluorogenic HDAC substrate 3 (5 mM)  BPS-50037 250 nmole
Fluorogenic HDAC class2a Substrate  BPS-50040 250 nmole

Fluorogenic HDAC Substrate1

BPS-50032

0,5 mol

 

 

 

Histone Deacetylase (HDAC) 

 

 

Histone Deacetylase 1 (HDAC1) (human) recombinant made in Sf9 insect cells

BPS-50001

50 ug

Histone Deacetylase 1 (HDAC1) (human) (recombinant) (His)

CAY-10009231-1

1 Vial 

Histone Deacetylase 2 (HDAC2) (human) recombinant made in Sf9 insect cells

BPS-50002

50 ug

Histone Deacetylase 2 (HDAC2) (human) (recombinant) (His)

CAY-10009377-1

1 Vial 

Histone Deacetylase 3 (HDAC3) (human) recombinant made in Sf9 insect cells

BPS-50003

50 ug

Histone Deacetylase 3 (HDAC3) (human) (recombinant) (His)

CAY-10009232-1

1 Vial 
HDAC3/NCOR1 Complex (human) (recombinant)  BML-SE515  

Histone Deacetylase 4 (HDAC4) (human) recombinant made in Sf9 insect cells

BPS-50004

2 ug

Histone Deacetylase 5 (HDAC5) (human) recombinant made in Sf9 insect cells

BPS-50045

2 ug

HDAC5 full length (Histone Deacetylase 5), human rec., (made in Sf9 insect cells)

BPS-50005

5 ug

Histone Deacetylase 5 (HDAC5) (human) (recombinant) (His)

CAY-10009379-1

1 Vial 

Histone Deacetylase 6 (HDAC6) (human) recombinant made in Sf9 insect cells

BPS-50006

50 ug

Histone Deacetylase 6 (HDAC6) (human) (recombinant) (GST)

CAY-10009465-1

1 pmol 

Histone Deacetylase 6 (HDAC6) (human recombinant)

CAY-10009465

inquire

Histone Deacetylase 7 (HDAC7) (human) recombinant made in Sf9 insect cells

BPS-50007

2 ug
Histone Deacetylase 8 (human) (recombinant)  BML-SE145   

Histone Deacetylase 8 (HDAC8) (human) recombinant made in Sf9 insect cells

BPS-50008

50 ug

Histone Deacetylase 8 (HDAC8) (human) (recombinant) (His)

CAY-10009380-1

1 Vial 

Histone Deacetylase 9 (HDAC9) (human) recombinant made in Sf9 insect cells

BPS-50009

5 ug

Histone Deacetylase 9 (HDAC9) (human) (recombinant) (His)

CAY-10009466-1

1 pmol 

Histone Deacetylase 9 (HDAC9) (human recombinant)

CAY-10009466

inquire

Histone Deacetylase 10 (HDAC10) (human)

BPS-50010

50 g

Histone Deacetylase 11 (HDAC11) (human) (under development)

BPS-50011

50 g

Histone Deacetylase (HDAC) (rat)

ALX-202-052-L002

2 ml 

  

 

 

Histone Deacetylase (HDAC) Antibodies

 

 

HDAC Family Antibody Set

BV-K333-11-30

1 Set 
        

Monoclonal Antibody to Histone Deacetylase 1 (HDAC)(10E2), Mouse IgG1

ALX-804-599-C200

200 g 

Polyclonal Antibody to Histone Deacetylase 1, (HDAC1) From rabbit.

ALX-210-256-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) rabbit

V13-40967

100 g

Polyclonal Antibody to Histone Deacetylase 1, (HDAC1) From rabbit.  

ABR-PA1-860-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 1 (HDAC1), Rabbit

ASB-ARP38530-T100

100 g 

Polyclonal Antibody to Histone Deacetylase 1 (HDAC1)

BV-3601-100

100 g 

Polyclonal Antibody to Histone Deacetylase 2, (HDAC2) From rabbit.

ALX-210-257-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 2, (HDAC2 ) From rabbit.  

ABR-PA1-861-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 2, (HDAC2 ) From rabbit.

ASB-ARP32618-P050

50 g 

Polyclonal Antibody to Histone Deacetylase 2 (HDAC2)

BV-3602-100

100 g 

Polyclonal Antibody to Histone Deactetylase 3, (HDAC3) From rabbit.

ALX-210-258-C100

100 g 

Polyclonal Antibody to Histone Deactetylase 3, (HDAC3) From rabbit.  

ABR-PA1-862-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 3 (HDAC3)

BV-3603-100

100 g 

Polyclonal Antibody to Histone Deacetylase 3 (HDAC3) rabbit pAb

V13-40968

100 g

Polyclonal Antibody to Histone Deacetylase 4 (HDAC4)(human) (CT), From rabbit.

ALX-210-338-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 4 (HDAC4)(NT), From rabbit.

ALX-210-339-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 4 (HDAC4)(human) (CT), From rabbit.  

ABR-PA1-863-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 4 (HDAC4)

BV-3604-100

100 g 

Polyclonal Antibody to Histone Deacetylase 4 (HDAC4) rabbit pAb

V13-40969

100 g

Polyclonal Antibody to Histone Deacetylase 4 (HDAC4)

BV-3604A-100

100 g 

Polyclonal Antibody to Histone Deacetylase 5, (HDAC5) From rabbit.

ALX-210-340-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 5 (HDAC5)

BV-3605-100

100 g 

Polyclonal Antibody to Histone Deacetylase 5 (HDAC5) rabbit pAb

V13-40970

100 g

Polyclonal Antibody to Histone Deacetylase 6, (HDAC5) From rabbit.

ALX-210-341-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 6 (HDAC6), Rabbit

ASB-ARP31451-P050

50 g 

Polyclonal Antibody to Histone Deacetylase 6 (HDAC6)

BV-3606-100

100 g 

Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) rabbit pAb

V13-40971

100 g

Polyclonal Antibody to Histone Deacetylase 7 (HDAC7)

BV-3607-100

100 g 

Polyclonal Antibody to Histone Deacetylase 8, (HDAC8) From rabbit.

ASB-ARP34587-P050

50 g 

Polyclonal Antibody to Histone Deacetylase 8 (HDAC8)

BV-3608-100

100 g 

Polyclonal Antibody to Histone Deacetylase 9 (HDAC9)

BV-3609-100

100 g 

Polyclonal Antibody to Histone Deacetylase 10 (HDAC10)

ABR-PA1-4289-C100

100 g 

Polyclonal Antibody to Histone Deacetylase 10 (HDAC10)

BV-3610-100

100 g 

Polyclonal Antibody to Histone Deacetylase 11 (HDAC11)

BV-3611P-100

100 g 

Polyclonal Antibody to Histone Deacetylase 11 (HDAC11) rabbit pAb

V13-39208

200 l

 

 

 

Histone Deacetylase (HDAC) Assay Kits

 

 
     
Fluor-de-Lys :  Gold Standard Kits for Acetylation Assays
See our in-house developed Fluor de Lys assay - a versatile non-radioactive assay for measuring HDAC and sirtuin activity. The Fluor de Lys assay system is compatible with all three classes of HDACs. A complete range of innovative HDAC, sirtuin and HAT reagents, including enzymes, substrates, antibodies, and inhibitors are now available.		  
   
Fluor-de-Lys Histone Deacetylase (HDAC) Fluorescent Activity Assay Kit BML-AK500   
Histone Deacetylase (HDAC) Colorimetric Activity Assay Kit BML-AK501   
HDAC Fluorimetric Cellular Activity Assay Kit BML-AK503   
HDAC1 Fluorimetric Drug Discovery Kit BML-AK511   
HDAC8 Fluorimetric Drug Discovery Kit BML-AK518   
SIRT2 Fluorescent Activity Assay/Drug Discovery Kit   BML-AK556   
Fluor-de-Lys BML-KI104   
Fluor-de-Lys-H4-AcK16 BML-KI174    
Fluor-de-Lys-SIRT1 BML-KI177    
Fluor-de-Lys-HDAC8 BML-KI178   
Fluor-de-Lys-SIRT2 BML-KI179   
Fluor-de-Lys Developer Concentrate BML-KI105   
Fluor-de-Lys Developer II BML-KI176   
Fluor-de-Lys Deacetylated Standard BML-KI142   

Histone Deacetylase HDAC Colorimetric Assay Kit

BV-K331-100

100 Assays 

 

BV-K331-1000

1000 Assays 
Fluorogenic HDAC assay kit BPS-50033 100 assays
Fluorogenic HDAC class2a assay kit 1 BPS-50041 100 assays

Histone Deacetylase HDAC Fluorometric Assay Kit

BV-K330-100

100 Assays 

 

BV-K330-1000

1000 Assays 

Histone Deacetylase HDAC Inhibitor Drug Screening Kit

BV-K340-100

100 Assays 

Histone Deacetylase HDAC Activity / Inhibitor Screening Assay Kit

CAY-789701-KI01

96 wells 

 

 

 

Histone Acetyltransferase (HAT) & related products

 

 

pCAF Histone Acetyltransferase (human) (rec.) (GST)

CAY-10009115-C025

25 ug

 

CAY-10009115-C050

50 ug

 

CAY-10009115-C100

100 ug

HAT Assay Kit (Fluorescent)

Quickly and easily assay for histone acetyltransferase (HAT) activity or screen HAT inhibitors with our new simple and sensitive fluorescent HAT assay kit. 

Fast 30-minute assay 
Flexible Contains both H3 and H4 peptides for use as substrate 
Complete Positive control p300 provided to screen a full 96-well plate of HAT inhibitors, while a potent HAT inhibitor is also supplied for testing HATs 

The histone acetyltransferase assay kit is a fluorescent method to assay samples for histone acetyltransferase (HAT) activity or to screen HAT inhibitors. The assay is easy to use, features a simple protocol that gives you results in 30 minutes and is ideal for high-throughput usage in 96-well plates. 
The HAT Assay Kit includes enough recombinant human p300 to screen 96 wells of inhibitor compounds, and anacardic acid is included for use as a control, as it is a potent HAT inhibitor. All assay buffers have been thoroughly tested to ensure that no components interfere with either activity or inhibition assays. Histone H3 and Histone H4 N-terminal peptides are included as a HAT substrates, so you can use the one best suited for your HAT enzyme. 

V13-56100

1 x 96 rxns
     

HAT Activity Assay Kit

Histone acetyltransferases (HATs) have been implicated to play a crucial role in various cellular functions, such as gene transcription, differentiation, and proliferation. BioVisions HAT Activity Colorimetric Assay Kit offers a convenient, nonradioactive system for a rapid and sensitive detection of HAT activity in mammalian samples. The kit utilizes active recombinant HAT as a positive control and acetyl-CoA as a cofactor. Acetylation of peptide substrate by active HAT releases the free form of CoA which then serves as an essential coenzyme for producing NADH. NADH can easily be detected spectrophotometrically upon reacting with a soluble tetrazolium dye. The detection can be continuous and suitable for kinetic studies. The kit provides a simple, straightforward protocol for a complete assay.

BV-K332-100

100 Assays

HAT Inhibitor Screening Assay Kit

CAY-10006515

96 wells
     

Histones

 

 

Histone H1-7 Substrate

ALX-158-001-M001

1 mg

 

ALX-158-001-M005

5 mg
     

Histone (calf thymus)

ALX-202-057-M010

10 mg

Histone H1 (calf thymus)

ALX-202-029-M001

1 mg

Histone H1 (calf thymus)

ALX-202-029-M005

5 mg

Histone H1.0 (human) (recombinant)

ALX-201-156-M001

1 mg

Histone H1.0 (human) (recombinant)

ALX-201-156-M005

5 mg

Histone H1.2 (human) (recombinant)

ALX-201-160-M001

1 mg

Histone H1.2 (human) (recombinant)

ALX-201-160-M005

5 mg

Histone H1.3 (human) (recombinant)

ALX-201-157-M001

1 mg

Histone H1.3 (human) (recombinant)

ALX-201-157-M005

5 mg

Histone H1.4 (human) (recombinant)

ALX-201-158-M001

1 mg

Histone H1.4 (human) (recombinant)

ALX-201-158-M005

5 mg

Histone H1.5 (human) (recombinant)

ALX-201-159-M001

1 mg

Histone H1.5 (human) (recombinant)

ALX-201-159-M005

5 mg

Histone gamma-H2AX (human) (recombinant)

ALX-201-176-M001

1 mg

Histone gamma-H2AX (human) (recombinant)

ALX-201-176-M005

5 mg

[Ala32]-Histone H2B (29-35)

ALX-158-002-M001

1 mg

[Ala32]-Histone H2B (29-35)

ALX-158-002-M005

5 mg

Histone H2B (29-35)

ALX-158-003-M001

1 mg

Histone H2B (29-35)

ALX-158-003-M005

5 mg

[Ala34]-Histone H2B (29-35)

ALX-158-004-M001

1 mg

[Ala34]-Histone H2B (29-35)

ALX-158-004-M005

5 mg

 

 

 

Antibodies to Histones

 

 

Monoclonal Antibody to Histone gamma-H2AX (phosphorylated) (pSer139) (3F2)

ABR-MA1-2022-C100

100 g

Monoclonal Antibody to Histone H3 (phosphorylated) (made in mouse)

V13-39211

100 g

Polyclonal Antibody to Histone gamma-H2AX (human) (phosphorylated) (pSer139)

ALX-210-390-R050

50 l

Polyclonal Antibody to Histone H2AX

BV-3761-100

100 ul

Polyclonal Antibody to Histone H2A

BV-3621-100

100 ug

Polyclonal Antibody to Histone H2A rabbit pAb

V13-39209

100 g

Polyclonal Antibody to Histone H2B rabbit pAb

V13-39210

100 g

Polyclonal Antibody to Histone H2B

BV-3622-100

100 ug

Polyclonal Antibody to Acetyl-Histone H2A

BV-3653-100

100 ug

Polyclonal Antibody to Acetyl-Histone H2B

BV-3654-100

100 ug

Polyclonal Antibody to Histone H3 rabbit pAb

V13-39088

100 g

Polyclonal Antibody to Histone H3

BV-3623-100

100 ug

Polyclonal Antibody to Acetyl-Histone H3

BV-3655-100

100 ug

Polyclonal Antibody to Histone H3 (human) (NT) (dimethylated Lys9)

CVL-PAB0189-1

1 Vial

Polyclonal Antibody to Histone H4

BV-3624-100

100 ug

Polyclonal Antibody to Histone H4 rabbit pAb

V13-39212

100 g

Polyclonal Antibody to Acetyl-Histone H4

BV-3656-100

100 ug
     

Other Products

 

 
p300 (human) (recombinant)  JBS-PR-762 2 g 
Recombinant p300 protein V13-31124 4 g
p300 (C-terminal Domain) (human) (recombinant)  JBS-PR-770 4 g 
p300 mouse mAb (32010125) V13-39519 100 l
Sirtuin 1, human rec., (made in E.coli) BPS-50012 100  g 
Sirtuin 2, human rec., (made in E.coli) BPS-50013 100   g  
Sirtuin 3, human rec., (made in E.coli) BPS-50014 100   g  
Sirtuin 4 , human rec., (made in E.coli) BPS-50015 100   g  
Sirtuin 5, human rec., (made in E.coli) BPS-50016 100   g  
Polyclonal Antibody to p300 (human), From rabbit.    ABR-PA1-848-C100 100 g 
Polyclonal Antibody to p300 (human), From rabbit.  ALX-210-228-C100 100 g
   

 

Blocking Peptides

 

 

Blocking Peptide for PAb to Histone Deacetylase 1 (Prod. No. ALX-210-256)

ALX-158-006-C050

50 g

Blocking Peptide for PAb to Histone Deacetylase 1 [HDAC1] (BV-3601)

BV-3601BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 2 (Prod. No. ALX-210-257)

ALX-158-007-C050

50 g 

Blocking Peptide for PAb to Histone Deacetylase 2 [HDAC2] (BV-3602)

BV-3602BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 3 (Prod. No. ALX-210-258)

ALX-158-008-C050

50 g

Blocking Peptide for PAb to Histone Deacetylase 3 [HDAC3] (BV-3603)

BV-3603BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 4 (human) (CT) (Prod. No. ALX-210-338)

ALX-158-009-C050

50 g

Blocking Peptide for PAb to Histone Deacetylase 4 [HDAC4] (BV-3604)

BV-3604BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 5 [HDAC5] (BV-3605)

BV-3605BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 6 [HDAC6] (BV-3606)

BV-3606BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 7 [HDAC7] (BV-3607)

BV-3607BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 8 [HDAC-8] (BV-3608)

BV-3608BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 9 [HDAC9] (BV-3609)

BV-3609BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 10 [HDAC10] (BV-3610)

BV-3610BP-50

50 ug

Blocking Peptide for PAb to Histone Deacetylase 11 [HDAC11] (BV-3611P)

Bv-3611BP-50

50 ug

  

 


Vinci-Biochem Cataloghi e Letteratura   Cerca Prodotti About us

 

 
Per ordini, richiedere preventivi o informazioni:
Vinci-Biochem - Via Ponte di Bagnolo, 10
50059 Vinci (Firenze)
Italia
Tel. 0571 568 147
Fax 0571 568 132
vb@vincibiochem.it

 

  

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