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50059 Vinci (Firenze)
Tel. +39 0571 568 147
vb@vincibiochem.it 
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Progranulin

 

Crescente interesse per questa proteina da parte dei Ricercatori impegnati nelle malattie neurodegenerative e non solo:
 
• Frontotemporal Lobar Degeneration (FTLD) 
• Huntingdon's disease
• Metabolism
• Alzheimer’s Disease (AD) 
• Schizophrenia
• Bipolar disorder (BPD) 
• Semantic Dementia (SD) 
• Progressive Non-Fluent Aphasia (PNFA)
• Alzheimer's disease (AD)
• Visceral Obesity, Elevated Plasma Glucose, and Dyslipidemia 
• Wound Healing
• Cartilage Repair
• Inflammation/Neuroinflammation Modulator
• Mitogenic and Tumor Promoting Effects
• Breast Cancer 
• Epithelial Ovarian Cancer (EOV) 
• Hepatocellular Carcinoma (HCC) 
• Cholangiocarcinom (CCA) 
• Nonalcoholic Fatty Liver Disease (NAFLD) 
 

Tag-free Progranulins – Unique Tools for in vivo Research

 
• Higher activity compared to tagged Progranulins
• Suitable for in vitro and in vivo studies
• Reflects the native sequence with no additional amino acids
• Correct processed protein (at the N-terminus)
• Affinity purified
• Low endotoxin levels (<0.1EU/μg)

Progranulin_2012

Scarica PDF

 
Progranulin (mouse) (rec.) (untagged) (BULK)
Produced in HEK293 cells. Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa. Purity: ≥95% (SDS-PAGE). Endotoxin Content: <0.1EU/μg protein (LAL-test).
AG-40A-0189
Progranulin (human) (rec.) (untagged) (BULK)
Produced in HEK293 cells. Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa. Purity: ≥95% (SDS-PAGE). Endotoxin Content: <0.1EU/μg protein (LAL-test).
AG-40A-0188
Progranulin (rat) (rec.) (untagged) 
Sequence Signal peptide and rat progranulin (aa 1-602) is untagged. Reflects the native sequence with no additional aa.  Purity  ≥90% (SDS-PAGE). Endotoxin Content  <0.1EU/μg purified protein (LAL test).  MW: ~65kDa (SDS-PAGE) 
AG-40A-0196
Progranulin (human) ELISA Kit (THE STANDARD)
Crossreactivity: Human Sample Type: Cell Culture Supernatant, Plasma, Serum Assay Type: Sandwich Detection Type: Colorimetric 
AG-45A-0018 
96 wells  /  2 x 96 wells  /  5 x 96 wells  
Progranulin (rat) ELISA Kit 
Crossreactivity: Rat Sample Type: Cell Culture Supernatant, Serum Assay Type: Sandwich Detection Type: Colorimetric
AG-45A-0043
96 wells  /  2 x 96 wells  /  5 x 96 wells  
Progranulin (mouse) ELISA Kit 
Crossreactivity: Mouse Sample Type: Cell Culture Supernatant, Serum Assay Type: Sandwich Detection Type: Colorimetric 
AG-45A-0019
96 wells  /  2 x 96 wells  /  5 x 96 wells  
Progranulin (human) (rec.) 
AG-40A-0068
Progranulin (mouse) (rec.) 
AG-40A-0080
Progranulin (rat) (rec.) 
MW: ~65kDa (SDS-PAGE) 
AG-40A-0194
anti-Progranulin (human), mAb (PG359-7) 
Crossreactivity: Human 
AG-20A-0052
anti-Progranulin (human), pAb 
Crossreactivity: Human 
AG-25A-0112
anti-Progranulin (mouse), pAb 
Crossreactivity: Mouse 
AG-25A-0093
anti-Progranulin (mouse), mAb (PG319-1) 
Crossreactivity: Mouse 
AG-20A-0077
 
   
 
 
Selected Review Articles
 
• Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration: R. Ghidoni, et al.; Neurology 71, 1235 (2008)
• Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008)
• The granulin gene family: from cancer to dementia: A. Bateman & H.P. Bennett; Bioassays 31, 1245 (2009)
• Serum biomarker for progranulin-associated frontotemporal lobar degeneration: K. Sleegers, et al.; Ann. Neurol. 65, 603 (2009)
• The molecular basis of frontotemporal dementia: M. Neumann, et al.; Expert Rev. Mol. Med. 11, (2009)
• Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update: I.R. Mackenzie, et al.; Acta Neuropathol. 119, 1 (2010)
• Sorting out frontotemporal dementia? J. Lewis & T.E. Golde; Neuron 68, 601 (2010)
• Structure, function, and mechanism of progranulin; the brain and beyond: H. Toh, et al.; J. Mol. Neurosci. 45, 538 (2011)
• Cellular effects of progranulin in health and disease: L. De Muynck & P. Van Damme; J. Mol. Neurosci. 45, 549 (2011)
• Progranulin and TDP-43: Mechanistic Links and Future Directions: S. Kumar-Singh; J. Mol. Neurosci. 45, 561 (2011)
• Progranulin: A promising therapeutic target for rheumatoid arthritis: C.J. Liu; FEBS Lett. 585, 3675 (2011)
• Progranulin: A growth factor, a novel TNFR ligand and a drug target: C.J. Liu & X. Bosch; Pharmacol. Ther. (2011)
• Optimal Plasma Progranulin Cutoff Value for Predicting Null Progranulin Mutations in Neurodegenerative Diseases: A Multicenter Italian Study: R. Ghidoni, et al.; Neurodegener. Dis. (2011)
• Frontotemporal Lobar Degeneration. Adv Exp Med Biol. Premi E, Padovani A, Borroni B. (2012)
• Behavioral Genetics of Neurodegenerative Disorders. Galimberti D, Scarpini E. Curr Top Behav Neurosci. (2012)
• Losing protein in the brain: the case of progranulin. Ghidoni R, , et al., Brain Res. (2012)
• TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.Colombrita C., et al., J Biol Chem. (2012)
• Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. Galimberti D, et al., Reif A. PLoS One. (2012)
• Optimal plasma progranulin cutoff value for predicting null progranulin mutations in neurodegenerative diseases: a multicenter Italian study.Ghidoni R., et al., Neurodegener Dis. (2012)
• Genetics of frontotemporal lobar degeneration. Galimberti D, Scarpini E. Front Neurol. (2012)
• Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Galimberti D., et al., Neurol Sci. (2012)
• Clinical phenotypes and genetic biomarkers of FTLD. Galimberti D, Scarpini E. J Neural Transm. (2012)
• Frontotemporal lobar degeneration: current knowledge and future challenges. Cerami C., et al., J Neurol. (2012)
• Prevalence of frontotemporal lobar degeneration in an isolated population: the Vallecamonica study. Gilberti N., et al., Neurol Sci. (2012)
• Circulating progranulin as a biomarker for neurodegenerative diseases. Ghidoni R., et al., Am J Neurodegener Dis. (2012)
• The progranulin (GRN) Cys157LysfsX97 mutation is associated with nonfluent variant of primary progressive aphasia clinical phenotype. Caso F., et al., J Alzheimers Dis. (2012)
• Gender Effects on Plasma PGRN Levels in Patients with Alzheimer's Disease: A Preliminary Study. Piscopo P., et al., J Alzheimers Dis. (2013)
• Estimating the age of the most common Italian GRN mutation: walking back to Canossa times. Benussi L., et al., J Alzheimers Dis. (2013)
 


 
 
 
Vinci-Biochem - Via Ponte di Bagnolo, 10
50059 Vinci (Firenze)
Italia
Tel. +39 0571 568 147
Fax +39 0571 568 132
vb@vincibiochem.it
 
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