Formulation
A solid
Purity
≥95%
MW
511,754
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A 5-HT5A antagonist (Ki = 6.31 nM); selective for 5-HT5A over a panel of 14 other receptors (Kis = >315 nM for all) but does inhibit SERT (Ki = 25.12 nM); decreases sphere formation in PDX breast cancer cells (IC50 = 596 nM); decreases tumor volume in combination with docetaxel in a PDX mouse model of breast cancer; inhibits cued fear conditioning in mice (ED50 = 25.4 mg/kg)
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).