Alloisolithocholic Acid
CAY-29542-25 25 mg
Synonyms: AILCA|AlloisoLCA|IsoalloLCA|Isoallolithocholic Acid|NSC 18169|β-hydroxy-5-Cholenoic Acid
Data Sheet: 
SDS:
SDS:
CAS
2276-93-9
Formulation
A solid
Purity
≥95%
MW
376,6
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Alloisolithocholic acid is a metabolite of the secondary bile acid metabolite 3-oxo lithocholic acid (dehydrolithocholic acid; Item No. 29544).{62987} It is formed from 3-oxo lithocholic acid by gut microbiota.{62987} Alloisolithocholic acid (20 µM) increases the association of the nuclear hormone receptor nerve growth factor IB (Nr4a1) to the gene encoding forkhead box protein P3 (Foxp3) in isolated mouse CD4+ T cells. It induces the differentiation of isolated mouse T cells into regulatory T cells (Tregs) and the production of mitochondrial reactive oxygen species (ROS) in isolated mouse CD4+ T cells when used at a concentration of 20 µM.{53583} Alloisolithocholic acid (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939} Fecal levels of alloisolithocholic acid are reduced in patients with Crohn’s disease or ulcerative colitis.{62987}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
