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Obesity / Diabetes Research

	Adipokine ELISA Kits / AdipoGen - NEW!! 2 pagine. Scarica pdf (0,4 Mb)
	FTO / AdipoGen - NEW!! 4 pagine. Scarica pdf (0,6 Mb) A Gene Contributing to Human Obesity
	NAMPT [PBEF/Visfatin] / AdipoGen - NEW!! 6 pagine. Scarica pdf (0,8 Mb) The NAD+ biosynthesis pathway in mammals consists of two steps involving the enzymes nicotinamide phosphoribosyltransferase (NAMPT [EC 2.4.2.12.]) and nicotinamide/nicotinic acid mononucleotide adenylyltransferase (Nmnat). NAMPT converts nicotinamide into nicotinamide mononucleotide (NMN) which then is converted to NAD+ by Nmnat. The rate limiting enzyme in the biosynthetic pathway of NAD+ is NAMPT. Originally, NAMPT was identified as pre-B cell colony enhancing factor (PBEF) a presumptive cytokinelike protein involved in subclinical inflammation. Later the protein was renamed visfatin, a visceral fat-derived adipocytokine believed to mimic insulin action. However this report was controversial resulting in the retraction of the paper. Although NAMPT may not directly bind to the insulin receptor as originally thought, NAMPT does regulate insulin secretion in β cells and can function as a cell survival factor.
	The FGF Family / AdipoGen - NEW!! 6 pagine. Scarica pdf (1,3 Mb)
	Catalogue OBESITY / Enzo Life Sciences 40 pagine. Scarica pdf (4,99 Mb) Leptin; Adiponectin; Nampt (Visfatin/PBEF); Retinol Binding Protein 4 [RBP4]; Vaspin; Omentin; Resistin; Apelin; IL-6 & TNF-α; Chemerin a Novel Adipokine; VEGF; Monocyte Chemoattractant Protein 1 [MCP1]; C1q Tumor Necrosis Factor-α-Related Proteins [CTRPs]; Angiopoietin-like Proteins [ANGPTLs]; Neuronal and Gastrointestinal Peptides: Ghrelin, Obestatin, Food Intake Regulators; Nesfatin; FTO; Fatty Acid Binding Proteins [FABPs]; C75; Stearoyl-CoA Desaturase 1 [SCD1].

ADIPOKINE ELISA KITS

References:

Adiponectin (human) ELISA Kit (AG-45A-0001)
Association between hypoadiponectinemia and cardiovascular risk factors in nonobese healthy adults: J.A. Im, et al.; Metabolism 55, 1546 (2006). Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth: E.S. Kim, et al.; Obesity (Silver Spring) 15, 3023 (2007). Obesity-related promotion of aberrant crypt foci in DMH-treated obese Zucker rats correlates with dyslipidemia rather than hyperinsulinemia: T.C. Koch, et al.; Eur. J. Nutr. 47, 161 (2008). Fat in liver/muscle correlates more strongly with insulin sensitivity in rats than abdominal fat: S. Lim, et al.; Obesity (Silver Spring) 17, 188 (2009). The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue: C. Veyrat-Durebex, et al.; Am. J. Physiol. Endocrinol. Metab. 296, E1120 (2009)

Adiponectin (mouse) ELISA Kit (AG-45A-0004)
Chop-deficient mice showed increased adiposity but no glucose intolerance: Y. Ariyama, et al.; Obesity (Silver Spring) 15, 1647 (2007). Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet: S. Otabe, et al.; Am. J. Physiol. Endocrinol. Metab. 293, E210 (2007). Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes: M. Kobayashi, et al.; Endocrinology 149, 5662 (2008)

Adiponectin (rat) ELISA Kit (AG-45A-0005)
A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells: E. Sonoda, et al.; Endocrinology 149, 4794 (2008). The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue: C. Veyrat-Durebex, et al.; Am. J. Physiol. Endocrinol. Metab. 296, E1120 (2009)

ANGPTL6 (human) ELISA Kit (AG-45A-0016)
Serum levels of angiopoietin-related growth factor are increased in preeclampsia: H. Stepan, et al.; Am. J. Hypertens. 22, 314 (2009)

Nampt (Visfatin/PBEF) (human) ELISA Kit (AG-45A-0006)
Molecular characteristics of serum visfatin and differential detection by immunoassays: A. Korner, et al.; J. Clin. Endocrinol. Metab. 92, 4783 (2007). Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study: R. Retnakaran, et al.; Clin. Endocrinol. (Oxf ) 69, 885 (2008). Adipokines influencing metabolic and cardiovascular disease are differentially regulated in maintenance hemodialysis: M. Ziegelmeier, et al.; Metabolism 57, 1414 (2008). Ethnic-specific Correlations of Visfatin With Circulating Markers of Endothelial Inflammation and Function: M. Reimann, et al.; Obesity (Silver Spring) Epub ahead of print, (2009). Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis: F. Lovren, et al.; Am. J. Physiol. Endocrinol. Metab. 296, E1440 (2009)

Progranulin (human) ELISA Kit (AG-45A-0018)
Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration: R. Ghidoni, et al.; Neurology 71, 1235 (2008). Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members: N. Finch, et al.; Brain 132, 583 (2009). Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia: R. Rademakers, et al.; Hum. Mol. Genet. 17, 3631 (2008). Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue: B.S. Youn, et al.; Diabetes 58, 627 (2009)

RBP4 (human) Competitive ELISA Kit (AG-45A-0010)
Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes: Y.M. Cho, et al.; Diabetes Care 29, 2457 (2006). Serum levels of adipokine retinol-binding protein-4 in relation to renal function: M. Ziegelmeier, et al.; Diabetes Care 30, 2588 (2007). Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressure: G. Hergenroeder, et al.; J. Neurotrauma 25, 79 (2008). Serum adipocyte fatty acidbinding protein levels are associated with nonalcoholic fatty liver disease in type 2 diabetic patients: J.H. Koh, et al.; Diabetes Care 32, 147 (2009). Elevated serum gammaglutamyltransferase levels are independently associated with insulin resistance in non-diabetic subjects: J.Y. Shin, et al.; Diabetes Res. Clin. Pract. 84, 152 (2009)

RBP4 (mouse/rat) Dual ELISA Kit (AG-45A-0012)
Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice: R. Sasaki, et al.; Biochem. Pharmacol. 74, 1619 (2007). Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice: N. Mody, et al.; Am. J. Physiol. Endocrinol. Metab. 294, E785 (2008). Diabetes of the Liver: The Link Between Nonalcoholic Fatty Liver Disease and HFCS-55: K.S. Collison, et al.; Obesity (Silver Spring) Epub ahead of print, (2009). Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo: A. Motani, et al.; J. Biol. Chem. 284, 7673 (2009)

Resistin (mouse) ELISA Kit (AG-45A-0024)
Sp1 mediates repression of the resistin gene by PPARgamma agonists in 3T3-L1 adipocytes: S.S. Chung, et al.; BBRC 348, 253 (2006)

Vaspin (human) ELISA Kit (AG-45A-0017)
Serum levels of the adipokine vaspin in relation to metabolic and renal parameters: J. Seeger, et al.; J. Clin. Endocrinol. Metab. 93, 247 (2008). Serum vaspin concentrations in human obesity and type 2 diabetes: B.S. Youn, et al.; Diabetes 57, 372 (2008). Serum vaspin levels in type 2 diabetic women in relation to microvascular complications: N.E. Gulcelik, et al.; Eur. J. Endocrinol. 160, 65 (2009). Vaspin serum concentrations in patients with carotid stenosis: G. Aust, et al.; Atherosclerosis 204, 262 (2009)