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Stress & Heat Shock Proteins
The highly conserved heat shock proteins (HSPs) are constitutively
expressed and function as molecular chaperones which facilitate the
synthesis and folding of proteins. They also participate in protein
assembly, export, turn-over and regulation. Under stressful conditions
such as heat shock, pH shift or hypoxia, increased expression of HSPs
protect the cell by stabilizing unfolded proteins, giving the cell time
to repair or re-synthesize damaged proteins.
Heat Shock Proteins (HSP) play a prominent role
in many of the cells most basic processes. Their general role as
molecular chaperones, protectors of the proteome, is now central to many
areas of active research including aging, neurodegeneration, signaling,
immunology and cancer.
To support cell stress response research, Enzo Life Sciences offers a
comprehensive portfolio of StressGen® products specific to the analysis
of Heat Shock Proteins (HSP). Products include: inhibitors, substrates,
proteins, antibodies, kits and a host of other products specific for the
HSP co-chaperones and client proteins.
The Enzo Life Sciences ELISA kits offer an easy and reproducible way to
quantitate various heat shock proteins including HSP70 and HSP90α.
For more details and to view our full range of Heat Shock products,
visit us at
www.enzolifesciences.com
HSP70 high sensitivity EIA kit
For the quantitative determination of HSP70 in serum and plasma of
human, mouse, and rat origin.
- Sensitive - quantify as little as 90 pg/ml
Hsp70
- Reliable fully validated for use with
serum and plasma samples
- Specific - measure Hsp72 with negligible
reactivity with other Hsp70 family members (e.g. Hsc70/Hsp73, Grp78)
- Higher throughput - measure ~40 samples in
duplicate in just 4.5 hours
HSP90α (human), EIA kit
For the quantitative determination of HSP90α; in cell lysates, serum,
and tissue of human origin.
- Reproducible - less than 10% variation
between assays
- Sensitive - use less precious sample per
test compared to Western blotting
- Quantitative - obtain precise,
statistically significant results facilitating comparison of data
between multiple experiments
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Cell Stress links
Web links to additional cell stress resources sponsored by
Cell Stress Society International.
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Molecular Chaperone Club
Club website that focuses on annual meeting held in Warwich,
Oxford, Cambridge, and other UK cities; publications;
scientific membership.
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Hsp90 website
A web site for the community of scientists interested in the
Hsp90 molecular chaperone machine.
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Picard laboratory
Features a table of interactions for Hsp90 and related
molecules.
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